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TMPyP4 tosylate

Cat. No. 4253 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of human telomerase
化学名： 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)
纯度： ≥95% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TMPyP4 tosylate

TMPyP4 tosylate is a cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.

技术数据 for TMPyP4 tosylate

分子量 1363.6
公式 C72H66N8O12S4
储存 Store at +4°C
纯度 ≥95% (HPLC)
CAS Number 36951-72-1
PubChem ID 11979833
InChI Key AKZFRMNXBLFDNN-UHFFFAOYSA-K
Smiles CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.C[N+]1=CC=C(C=C1)C1=C2\C=CC(=N2)\C(=C2/N\C(\C=C2)=C(/C2=N/C(/C=C2)=C(\C2=CC=C\1N2)C1=CC=[N+](C)C=C1)C1=CC=[N+](C)C=C1)\C1=CC=[N+](C)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TMPyP4 tosylate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 68.18 50

制备储备液 for TMPyP4 tosylate

以下数据基于产品分子量 1363.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 1.47 mL 7.33 mL 14.67 mL
2.5 mM 0.29 mL 1.47 mL 2.93 mL
5 mM 0.15 mL 0.73 mL 1.47 mL
25 mM 0.03 mL 0.15 mL 0.29 mL

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产品说明书 for TMPyP4 tosylate

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for TMPyP4 tosylate

参考文献是支持产品生物活性的出版物。

Rha et al (2000) Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 6 987 PMID: 10741725

Shammas et al (2003) Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2 825 PMID: 14555701

Wheelhouse et al (1998) Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc. 120 3261

Shi et al (2001) Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem. 474 4509

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关键词: TMPyP4 tosylate, TMPyP4 tosylate supplier, TMPyP4, telomerase, inhibitors, inhibits, g, tetrads, quadruplex, DNA, telomeres, Telomerase, 4253, Tocris Bioscience

1 篇 TMPyP4 tosylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TMPyP4 tosylate 的部分引用包括：

Ole et al (2019) Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts. Hum Mol Genet 28 3232-3243 PMID: 31261377

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