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Submit ReviewTobramycin is an aminoglycoside antibiotic. Exhibits antibacterial activity against strains of Enterobacteriaceae, Pseudomonas and Staphylococcus aureus. Shown to protect lung epithelial cells in vitro against injury from cystic fibrosis bronchial secretions and H2O2.
分子量 | 467.52 |
公式 | C18H37N5O9 |
储存 | Store at +4°C |
CAS Number | 32986-56-4 |
PubChem ID | 36294 |
InChI Key | NLVFBUXFDBBNBW-PBSUHMDJSA-N |
Smiles | O[C@H]1C[C@@H](N)[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)([H])O[C@@H]1CN |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 46.75 | 100 |
以下数据基于产品分子量 467.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.14 mL | 10.69 mL | 21.39 mL |
5 mM | 0.43 mL | 2.14 mL | 4.28 mL |
10 mM | 0.21 mL | 1.07 mL | 2.14 mL |
50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
参考文献是支持产品生物活性的出版物。
Dienstag and Neu (1972) In vitro studies of tobramycin, an aminoglycoside antibiotic. Antimicrob.Agents Chemother. 1 41 PMID: 4670427
Cantin and Woods (1993) Protection by antibiotics against myeloperoxidase-dependent cytotoxicity to lung epithelial cells in vitro. PMID: 8380814
If you know of a relevant reference for Tobramycin, please let us know.
关键词: Tobramycin, Tobramycin supplier, aminoglycoside, antibiotics, antibacterial, Antibiotics, 5390, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。
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Mechanism of action of tobramycin was studied along with other aminoglycoside antibiotics such as neomycin and gentamicin.Clinical isolate of P. aeruginosa, PAO1 (PAO1-RH) used to do susceptibility tests.