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说明： Potent PDGFR and VEGFR inhibitor
别名： Palladia
化学名： 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
纯度： ≥98% (HPLC)
生物活性 for Toceranib
Toceranib is a potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo.
许可信息
Sold for research purposes under agreement from Pfizer.
技术数据 for Toceranib
| 分子量 | 396.46 |
| 公式 | C22H25FN4O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 356068-94-5 |
| PubChem ID | 5329106 |
| InChI Key | SRSGVKWWVXWSJT-ATVHPVEESA-N |
| Smiles | O=C2NC1=CC=C(F)C=C1/C2=C/C3=C(C)C(C(NCCN4CCCC4)=O)=C(C)N3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Toceranib
参考文献 for Toceranib
参考文献是支持产品生物活性的出版物。
Liao et al (2002) Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 100 585 PMID: 12091352
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关键词: Toceranib, Toceranib supplier, Potent, PDGFR, VEGFR, inhibitors, inhibits, c-kit, FGFR1, mast, cell, cycle, arrest, apoptosis, tumors, tumours, Palladia, Cell, Cycle, Inhibitors, Apoptosis, Inducers, 3909, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.