Tocriscreen GPCR Compound Library

Cat. No. 8100 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： A bioactive compound library of 240 GPCR compounds (100 μL 10 mM DMSO solutions) for high-throughput screening, high-content screening, target validation and assay development

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生物活性 for Tocriscreen GPCR Compound Library

Tocriscreen GPCR Compound Library is a library of 240 compounds (100 μl, 10 mM) for GPCR research. Contains compounds that target >30 types of GPCR, including peptide receptors, 5-HT receptors, chemokine receptors, adenosine receptors, adrenergic receptors and more. Adapted for popular techniques in drug discovery and cell biology research, including high throughput screening, high content screening, target validation and assay development. Please view the GPCR tree image for a closer look at the pharmacological diversity of this compound library.

If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.

Scientific Data

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Class A GPCR phylogenetic tree illustrating the pharmacological diversity of the Tocriscreen GPCR Compound Library. The 240 compounds in the Tocriscreen GPCR Compound Library target over 120 GPCRs. Targets are evenly spread across all the GPCR classes with a particular focus on class A, mixing well-established targets such as 5-HT and adenosine receptors, as well as orphan GPCRs such as GPR35 and GPR171. To view a larger PDF version of this image, please click on the ‘GPCR tree’ link in the product description.Adapted from GPCRdb (www.gpcrdb.org/ligand/coverage).

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Chemical diversity of the Tocriscreen GPCR Compound Library. The image shows the overlapping chemical space of the 240 compounds in the Tocriscreen GPCR Compound Library (green dots) in relation to the chemical space occupied by the ChEMBL GPCR compound Chemical Space* (grey dots). Each dot represents a unique fingerprint generated from each compound’s 3D molecular structure. The even distribution of the fingerprints of the compounds in the Tocriscreen GPCR Compound Library highlights the chemical diversity of this library.*The ChEMBL GPCR compound Chemical Space used for this study is defined as a subset of ChEMBL with activities < 1 μM on any of the GPCRs listed in ChEMBL, with a molecular weight between 150 and 550 Da, AlogP between (-2) and 6 and a maximum of one Lipinski rule of 5 violation. This subset contains over 77k compounds.

Key Format and Product Details for Tocriscreen GPCR Compound Library

96-well racks with Matrix storage tubes & SepraSeal caps
Pre-dissolved in DMSO
Compounds arranged 80 per rack with 3 racks per library

Many compounds are exclusive to Tocris
Full chemical and biological data available
Exceptional purity

GPCR types targeted by the Tocriscreen GPCR Library

Major GPCR subfamilies covered by Tocriscreen GPCR Library. Peptide Receptors (20%), 5-HT Receptors (10%), Chemokine Receptors (8%), Adenosine Receptors (7%), Adrenergic Receptors (7%), Dopamine Receptors (6%), mGlu Receptors (5%), Opioid Receptors (4%), Muscarinic Receptors (4%), S1P Receptors (4%), Other (26%).

索取化合物列表

如需索取 Tocriscreen GPCR Compound Library 中包含的化合物列表，请点击下方的索取图块。化合物列表以 Excel 或 SD 格式提供。

索取化合物列表： Tocriscreen GPCR Compound Library

技术数据 for Tocriscreen GPCR Compound Library

储存	Store at -20°C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

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参考文献 for Tocriscreen GPCR Compound Library

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Tocriscreen™ Compound Libraries

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