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Submit ReviewTopiramate
说明： GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors
别名： Topamax
化学名： 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
纯度： ≥99% (HPLC)
生物活性 for Topiramate
Topiramate is an anticonvulsant. Antagonizes GluK1 (formerly GluR5) kainate receptors (IC50 = 0.46 μM), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
化合物库 for Topiramate
Topiramate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Topiramate
| 分子量 | 339.36 |
| 公式 | C12H21NO8S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 97240-79-4 |
| PubChem ID | 5284627 |
| InChI Key | KJADKKWYZYXHBB-XBWDGYHZSA-N |
| Smiles | CC(O2)(C)O[C@H]1[C@@H]2[C@H](OC(C)(C)O3)[C@@]3(COS(N)(=O)=O)OC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Topiramate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.94 | 100 | |
| ethanol | 33.94 | 100 |
制备储备液 for Topiramate
以下数据基于产品分子量 339.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.73 mL | 29.47 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.89 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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产品说明书 for Topiramate
参考文献 for Topiramate
参考文献是支持产品生物活性的出版物。
Zona et al (1997) Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells. Neurosci.Lett. 231 123 PMID: 9300637
Dodgson et al (2000) Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia 41 S35 PMID: 10768298
Gryder and Rogawski (2003) Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topir. in rat basolateral amygdala neurons. J.Neurosci. 23 7069 PMID: 12904467
Kaminiski et al (2004) Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology 46 1097 PMID: 15111016
If you know of a relevant reference for Topiramate, please let us know.
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关键词: Topiramate, Topiramate supplier, GluR5, antagonists, anticonvulsant, GABAA, receptor, positive, allosteric, modulators, Glutamate, Kainate, Receptors, iGluR, Ionotropic, GluK1, PAM, Topamax, Carbonic, anhydrases, 3620, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Topiramate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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