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说明： Inhibitor of cholesteryl ester transfer protein (CETP)
化学名： (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylic acid ethyl ester
纯度： ≥99% (HPLC)
生物活性 for Torcetrapib
Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for Torcetrapib
| 分子量 | 600.47 |
| 公式 | C26H25F9N2O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 262352-17-0 |
| PubChem ID | 159325 |
| InChI Key | CMSGWTNRGKRWGS-NQIIRXRSSA-N |
| Smiles | CC[C@H]2N(C(OCC)=O)C1=CC=C(C(F)(F)F)C=C1[C@@H](N(CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C(OC)=O)C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Torcetrapib
参考文献 for Torcetrapib
参考文献是支持产品生物活性的出版物。
Connelly et al (2010) Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition. J.Cardiovascular Pharmacol. 55 459 PMID: 20051879
Forrest et al (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone. Br.J.Pharmacol. 154 1465 PMID: 18536749
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关键词: Torcetrapib, Torcetrapib supplier, hypercholesterolemia, inhibits, cholesteryl, ester, transferase, protein, CETP, impairs, endothelial, function, Other, Transferases, Lipid, Metabolism, 4184, Tocris Bioscience
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