TP 003

Cat. No. 4414 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： GABA_A partial agonist; acts at benzodiazepine site

化学名： 2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile

纯度： ≥98% (HPLC)

引用文献 (3)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TP 003

TP 003 is a GABA_A receptor partial agonist that demonstrates affinity for the benzodiazepine site. Potentiates GABA_A α3 response with high efficacy. Produces anxiolytic-like effects in rodent elevated plus maze via action at GABA_A α2 subtype receptors. Also evokes GABA_A α1 mediated sedation and GABA_A α3 mediated muscle relaxation in mice.

化合物库 for TP 003

TP 003 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TP 003

分子量	407.39
公式	C₂₃H₁₆F₃N₃O
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	628690-75-5
PubChem ID	10001434
InChI Key	SJMMDWXJSSJHOQ-UHFFFAOYSA-N
Smiles	FC1=C(C(C)(O)C)C=CN2C1=NC=C2C3=CC=C(F)C(C4=CC=C(F)C=C4C#N)=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TP 003

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	40.74	100
	ethanol	20.37	50

制备储备液 for TP 003

以下数据基于产品分子量 407.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.27 mL	24.55 mL
5 mM	0.49 mL	2.45 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.45 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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产品说明书 for TP 003

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TP 003

参考文献是支持产品生物活性的出版物。

Dias et al (2005) Evidence for a significant role of α3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J.Neurosci. 25 10682 PMID: 16291941

Fischer et al (2011) Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys. Psychopharmacology (Berl.) 215 311 PMID: 21190016

Neumann et al (2018) TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA_A receptors. Neuropharmacology 143 71 PMID: 30240781

If you know of a relevant reference for TP 003, please let us know.

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关键词: TP 003, TP 003 supplier, TP003, GABAA, GABA, receptors, a3, alpha3, α3, agonists, anxiolytic, Receptors, 4414, Tocris Bioscience

3 篇 TP 003 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TP 003 的部分引用包括：

Seifi et al (2018) GABAA Receptor Subtypes Regulate Stress-Induced Colon Inflammation in Mice. Gastroenterology 155 852 PMID: 29802853

Soderhielm et al (2018) Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABA_A receptors. Biochem Pharmacol 158 339 PMID: 30121248

Seifi et al (2014) Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. Gastroenterology 34 10361 PMID: 25080596

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