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Submit ReviewTRAM 34
说明： Potent and highly selective KCa3.1 (IK) channel blocker
化学名： 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
纯度： ≥99% (HPLC)
生物活性 for TRAM 34
TRAM 34 is a potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
技术数据 for TRAM 34
| 分子量 | 344.84 |
| 公式 | C22H17ClN2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 289905-88-0 |
| PubChem ID | 656734 |
| InChI Key | KBFUQFVFYYBHBT-UHFFFAOYSA-N |
| Smiles | ClC(C=CC=C4)=C4C(N2C=CC=N2)(C3=CC=CC=C3)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TRAM 34
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 3.45 | 10 温和加热 |
制备储备液 for TRAM 34
以下数据基于产品分子量 344.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29 mL | 144.99 mL | 289.99 mL |
| 0.5 mM | 5.8 mL | 29 mL | 58 mL |
| 1 mM | 2.9 mL | 14.5 mL | 29 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.8 mL |
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产品说明书 for TRAM 34
参考文献 for TRAM 34
参考文献是支持产品生物活性的出版物。
Schilling and Eder (2007) TRAM-34 inhibits nonselective cation channels. Pflugers Arch. 454 559 PMID: 17318643
Wang et al (2007) An intermediate-conductance Ca2+-activated K+ channel mediates B lymphoma cell cycle progression induced by serum. Pflugers Arch. 454 945 PMID: 17429684
Wulff et al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci. USA 97 8151
If you know of a relevant reference for TRAM 34, please let us know.
关键词: TRAM 34, TRAM 34 supplier, selective, IKCa1, channel, blockers, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, TRAM34, KCa3.1, Ca2+-Activated, 2946, Tocris Bioscience
10 篇 TRAM 34 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TRAM 34 的部分引用包括：
Mazzuca et al (2015) Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther 352 291 PMID: 25472954
Agarwal et al (2013) TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity. FASEB J 8 e63028 PMID: 23667566
Chan and Cipolla (2011) Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γ. JCI Insight 25 3229 PMID: 21602449
Zemkova et al (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176
Yu (2017) Functional cooperation between KCa3.1 and TRPV4 channels in bronchial smooth muscle cell proliferation associated with chronic asthma. Front. Pharmacol 8 559 PMID: 28970794
Chien and Su (2015) 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. PLoS One 22 42 PMID: 26076928
Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695
Kanthesh et al (2013) Enhanced K(+) secretion in dextran sulfate-induced colitis reflects upregulation of large conductance apical K(+) channels (BK; Kcnma1). Am J Physiol Cell Physiol 305 C972 PMID: 23986198
Engbers et al (2012) Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. Elife 109 2601 PMID: 22308379
Cahalan et al (2015) Piezo1 links mechanical forces to red blood cell volume. J Biomed Sci 4 PMID: 26001274
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TRAM 34 的评论
平均评分: 4 (Based on 1 Review.)
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TRAM 34 worked ideally as a channel blocker on different cell lines.
By
Sadequl Islam on 10/13/2018
分析类型： In Vitro
种属： Human
Product used for understanding blocking mechanism of calcium activated potassium channel. Product must be dissolved in DMSO, on mild heat. Shows great potential for research in KCa channel studies.
