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TRAM 39

Cat. No. 4952 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4952 has been discontinued.

View all Calcium-Activated Potassium (K<sub>Ca</sub>) Channels products.
说明： Potent KCa3.1 (IK) blocker
化学名： 2-Chloro-α,α-diphenylbenzeneacetonitrile
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for TRAM 39

TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.

技术数据 for TRAM 39

分子量 303.78
公式 C20H14ClN
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 197525-99-8
PubChem ID 9861261
InChI Key JHNRTPKGSCVKKC-UHFFFAOYSA-N
Smiles ClC(C=CC=C3)=C3C(C2=CC=CC=C2)(C#N)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TRAM 39

参考文献是支持产品生物活性的出版物。

Wulff et al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci.U.S.A. 97 8151 PMID: 10884437

Burnham et al (2006) Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br.J.Pharmacol. 148 434 PMID: 16682967

Ayabe et al (2002) Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J.Biol.Chem. 277 3793 PMID: 11724775

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关键词: TRAM 39, TRAM 39 supplier, TRAM39, potent, intermediate, conductance, calcium, Ca2+, actiavted, potassium, K+, channels, blockers, blocks, KCa3.1, IKCa1, ion, Ca2+-Activated, Potassium, Channels, 4952, Tocris Bioscience

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TRAM 39 的评论

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Selective blocker worked ideally to block Calcium activated K+ channels.
By Anonymous on 10/22/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK 293

Product was used on BK channel.Calcium activated potassium channels were expressed by HEK 293 cells which was used for the study.It shows moderate blocking activity and the data patterns were similar throughout the study.

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