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Tranilast

Cat. No. 1098 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Antiallergic; inhibits inflammatory mediator release from mast cells
化学名： 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Tranilast

Tranilast is an antiallergic via inhibition of chemical mediator release from mast cells. Shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT1 receptor. Inhibits TRPV2-mediated responses; binds to Aβ40 monomers and increases Aβ40 fibrillation.

化合物库 for Tranilast

Tranilast is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Tranilast

分子量 327.34
公式 C18H17NO5
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 53902-12-8
PubChem ID 5282230
InChI Key NZHGWWWHIYHZNX-CSKARUKUSA-N
Smiles COC1=CC=C(\C=C\C(=O)NC2=CC=CC=C2C(O)=O)C=C1OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tranilast

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.73 100

制备储备液 for Tranilast

以下数据基于产品分子量 327.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.27 mL 30.55 mL
5 mM 0.61 mL 3.05 mL 6.11 mL
10 mM 0.31 mL 1.53 mL 3.05 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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产品说明书 for Tranilast

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Tranilast

参考文献是支持产品生物活性的出版物。

Hishikawa et al (1996) Tranilast restores cytokine-induced nitric oxide production against platelet derived growth factor in vascular smooth muscle cells. J.Cardiovasc.Pharmacol. 28 200 PMID: 8856474

Isaji et al (1997) Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br.J.Pharmacol. 122 1061 PMID: 9401770

Jin et al (1998) Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II. Eur.J.Pharmacol. 361 199 PMID: 9865509

Hisanaga et al (2009) Regulation of calcium-permeable TRPV2 channel by Ins in pancreatic beta-cells. Diabetes. 58 174 PMID: 18984736

Connors et al (2013) Tranilast binds to Aβ monomers and promotes Aβ fibrillation. Biochemistry PMID: 23679559

If you know of a relevant reference for Tranilast, please let us know.

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关键词: Tranilast, Tranilast supplier, Anti-allergic, inhibits, inhibitors, release, mast, cells, Antiangiogenics, TRPV2, amyloid, beta, AB, monomers, alzheimers, amyloidbeta, amyloidb, amyloidβ, Miscellaneous, Compounds, TRPV, Amyloid, Beta, Peptides, 1098, Tocris Bioscience

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