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Treprostinil

Cat. No. 5349 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent prostacyclin (PGI2) analog
化学名： 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Treprostinil

Treprostinil is a potent prostacyclin (PGI2) analog (EC50 values are 0.6, 1.9 and 6.2 nM at DP1, IP and EP2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NFκB nuclear translocation in human alveolar macrophages in vitro.

技术数据 for Treprostinil

分子量 390.51
公式 C23H34O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 81846-19-7
PubChem ID 6918140
InChI Key PAJMKGZZBBTTOY-ZFORQUDYSA-N
Smiles O[C@H](C3)[C@H](CC[C@@H](O)CCCCC)[C@@]([C@@]3([H])C2)([H])CC1=C2C(OCC(O)=O)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Treprostinil

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.05 100
ethanol 19.53 50

制备储备液 for Treprostinil

以下数据基于产品分子量 390.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.8 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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产品说明书 for Treprostinil

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Treprostinil

参考文献是支持产品生物活性的出版物。

Whittle et al (2012) Binding and activity of the prostacyclin receptor (IP) agonists, trepros. and iloprost, at human prostanoid receptors: trepros. is a potent DP1 and EP2 agonist. Biochem.Pharmacol. 84 68 PMID: 22480736

Raychaudhuri et al (2002) The prostacyclin analogue trepros. blocks NFκB nuclear translocation in human alveolar macrophages. J.Biol.Chem. 277 33344 PMID: 12082102

Fontana et al (2007) Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes. Br.J.Pharmacol. 151 779 PMID: 17533419

If you know of a relevant reference for Treprostinil, please let us know.

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关键词: Treprostinil, Treprostinil supplier, Potent, prostacyclin, PGI2, analogues, DP,IP, EP2, agonists, agonism, vasodilation, pulmonary, hypertension, PPH, Prostanoid, Receptors, 5349, Tocris Bioscience

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