Trofinetide

Cat. No. 7937 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： IGF-1 synthetic analogue

化学名： Glycyl-2-methyl-L-prolyl-L-glutamic acid

纯度： ≥98% (HPLC)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Trofinetide

Trofinetide is an IGF-1 synthetic analog. It suppresses expression of IL-1β, TNF-α, IFN-γ and E-selectin, and inhibits both acute and delayed neuroinflammation following penetrating ballistic-like brain injury (PBBI) in rats.

技术数据 for Trofinetide

分子量	315.32
公式	C₁₃H₂₁N₃O₆
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	853400-76-7
InChI Key	BUSXWGRAOZQTEY-SDBXPKJASA-N
Smiles	C(N[C@@H](CCC(O)=O)C(O)=O)(=O)[C@@]1(C)N(C(CN)=O)CCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Trofinetide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	31.53	100
	DMSO	15.77	50 温和加热

制备储备液 for Trofinetide

以下数据基于产品分子量 315.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.17 mL	15.86 mL	31.71 mL
5 mM	0.63 mL	3.17 mL	6.34 mL
10 mM	0.32 mL	1.59 mL	3.17 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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产品说明书 for Trofinetide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Trofinetide

参考文献是支持产品生物活性的出版物。

Wei et al (2009) NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J.Neuroinflammation 6 19 PMID: 19656406

If you know of a relevant reference for Trofinetide, please let us know.

按标靶查看相关产品

关键词: Trofinetide, Trofinetide supplier, IGF1, synthetic, analogue, in, vivo, cytokine, inflammatory, IL-1β, IFN-γ, E-selectin, neuroinflammation, PBBI, penetrating, ballistic-like, brain, injury, NNZ-2566, NNZ2566, Insulin, and, insulin-like, Receptors, Cytokines, 7937, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Trofinetide

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.