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TRPV3 74a

Cat. No. 6831 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective TRPV3 antagonist; brain penetrant
化学名： (αS)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TRPV3 74a

TRPV3 74a is a selective TRPV3 antagonist (KB = 0.56 μM). Displays no significant activity against a panel of other ion channels. Exhibits efficacy in animal models of neuropathic pain. Brain penetrant.

技术数据 for TRPV3 74a

分子量 338.32
公式 C17H17F3N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1432051-63-2
PubChem ID 71554840
InChI Key MTJXDHFAWXGXIN-OAGGEKHMSA-N
Smiles C[C@]1(C[C@@]([C@@H](C2=CC=CC=N2)O)(C3=CC(C(F)(F)F)=CC=N3)C1)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TRPV3 74a

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.83 100

制备储备液 for TRPV3 74a

以下数据基于产品分子量 338.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.56 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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参考文献 for TRPV3 74a

参考文献是支持产品生物活性的出版物。

Gomtsyan et al (2016) Synthesis and pharmacology of (pyridin-2-yl)methanol derivatives as novel and selective transient receptor potential vanilloid 3 antagonists. J.Med.Chem. 59 4926 PMID: 27077528

If you know of a relevant reference for TRPV3 74a, please let us know.

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关键词: TRPV3 74a, TRPV3 74a supplier, TRPV374a, Transient, Receptor, Potential, Channels, vanilloids, antagonists, antagonism, TRPV3, selective, brain, penetrant, neuropathic, pain, TRPV, 6831, Tocris Bioscience

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