U 46619

Cat. No. 1932 9 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, stable thromboxane A₂ (TP) receptor agonist

别名： 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F_2a

化学名： (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid

纯度： ≥98% (HPLC)

引用文献 (9)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for U 46619

U 46619 is a PGH₂ (TXA₂) analog that is a potent and stable thromboxane A₂ (TP) receptor agonist (EC₅₀ = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.

技术数据 for U 46619

分子量	350.5
公式	C₂₁H₃₄O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	56985-40-1
PubChem ID	5311493
InChI Key	LQANGKSBLPMBTJ-BRSNVKEHSA-N
Smiles	O[C@@H](CCCCC)/C=C/[C@H]1[C@@H]2OC[C@@H](C2)[C@@H]1C/C=C\CCCC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for U 46619

溶解性	Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

产品说明书 for U 46619

分析证书/产品说明书

化学品安全技术说明书

参考文献 for U 46619

参考文献是支持产品生物活性的出版物。

Coleman et al (1981) Comparison of the actions of U-46619, a prostaglandin H₂-analogue, with those of prostaglandin H₂ and thromboxane A₂ on some isolated smooth muscle preparations. Br.J.Pharmacol. 73 773 PMID: 7248665

Morinelli et al (1987) Receptor-mediated effects of a PGH₂ analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035 PMID: 3688248

Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A₂ receptor. Mol.Pharmacol. 61 817 PMID: 11901221

If you know of a relevant reference for U 46619, please let us know.

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关键词: U 46619, U 46619 supplier, Potent, stable, thromboxane, A2, TP, receptor, agonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, U46619, 9, 11-Dideoxy-9a, 11a-methanoepoxy, prostaglandinF2a, 9,11-Dideoxy-9a,11a-methanoepoxy, prostaglandin, F2a, Receptors, 1932, Tocris Bioscience