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Submit ReviewUCL 1684
说明： Highly potent KCa2 (SK) channel blocker
化学名： 6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-11,7-metheno-7H-dibenzo [b,n] [1,5,12,16]tetraazacyclotricosine-5,13-diium dibromide
纯度： ≥97% (HPLC)
生物活性 for UCL 1684
UCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons). Blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively.
许可信息
Sold with the permission of University College, London
技术数据 for UCL 1684
| 分子量 | 654.44 |
| 公式 | C34H30Br2N4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 199934-16-2 |
| PubChem ID | 9852584 |
| InChI Key | KPNMQIKQVCWNTP-UHFFFAOYSA-N |
| Smiles | C12=CC=CC=C1C(NCC4=CC=C(CNC5=CC=[N+]7C6=C5C=CC=C6)C=C4)=CC=[N+]2CC3=CC=CC(C7)=C3.[Br-].[Br-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for UCL 1684
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 7.21 | 10 |
制备储备液 for UCL 1684
以下数据基于产品分子量 654.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.28 mL | 76.4 mL | 152.8 mL |
| 0.5 mM | 3.06 mL | 15.28 mL | 30.56 mL |
| 1 mM | 1.53 mL | 7.64 mL | 15.28 mL |
| 5 mM | 0.31 mL | 1.53 mL | 3.06 mL |
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产品说明书 for UCL 1684
参考文献 for UCL 1684
参考文献是支持产品生物活性的出版物。
Campos Rosa et al (2000) Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel. J.Med.Chem. 43 420 PMID: 10669569
Malik-Hall et al (2000) Compounds that block intermediate-conductance (IKCa) and small-conductance (SKCa) calcium-activated potassium channels. Br.J.Pharmacol. 129 1431 PMID: 10742299
Strobaek et al (2000) Pharmacological characterization of small-conductance Ca2+-activated K+ channels stably expressed in HEK 293 cells. Br.J.Pharmacol. 129 991 PMID: 10696100
If you know of a relevant reference for UCL 1684, please let us know.
关键词: UCL 1684, UCL 1684 supplier, potent, blockers, SKCa, Potassium, Channels, K+, ca2+-activated, ca2+-dependent, SK1, SK2, UCL1684, Ca2+-Activated, 1310, Tocris Bioscience
13 篇 UCL 1684 的引用文献
引用文献是使用了 Tocris 产品的出版物。 UCL 1684 的部分引用包括：
Lamy et al (2010) Allosteric block of KCa2 channels by apamin. PLoS One 285 27067 PMID: 20562108
Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Heart Rhythm 173 177 PMID: 26454020
Szollosi et al (2007) Glucose stimulates Ca2+ influx and Ins secretion in 2-week-old β-cells lacking ATP-sensitive K+ channels. Br J Pharmacol 282 1747 PMID: 17138557
Kurahashi et al (2014) Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles. Am J Physiol Cell Physiol 307 C561 PMID: 25055825
Hsueh et al (2013) Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium. J Biomed Sci 10 891 PMID: 23376397
Geier et al (2011) Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels. Am J Physiol Cell Physiol 300 C937 PMID: 21228322
Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695
Alpert and Alford (2013) Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons. PLoS One 8 e63154 PMID: 23646190
Chien and Su (2015) 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. J Biol Chem 22 42 PMID: 26076928
Giachini et al (2009) Upregulation of intermediate calcium-activated potassium channels counterbalance the impaired endothelium-dependent vasodilation in stroke-prone spontaneously hypertensive rats. Transl Res 154 183 PMID: 19766962
Oliveira et al (2010) Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in PilC-treated epileptic rats. Brain Res 1348 187 PMID: 20553876
Coleman et al (2014) New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol Pharmacol 86 342 PMID: 24958817
Hilgers et al (2010) Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries. J Pharmacol Exp Ther 333 210 PMID: 20040579
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UCL 1684 的评论
平均评分: 5 (Based on 1 Review.)
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UCL 1684 is a very potent non-peptidic blocker of Calcium activated potassium channels.
By
Anonymous on 10/23/2018
分析类型： In Vitro
种属： Human
UCL 1684 is a potent non-peptidic blocker of the apamin-sensitive Ca2+ -activated K+ channel. The product works ideally on cell culture labs and would highly recommend.
