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Submit ReviewUCL 2077
Discontinued Product
2661 has been discontinued.
View all Calcium-Activated Potassium (K<sub>Ca</sub>) Channels products.
说明： Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects
化学名： N-Trityl-3-pyridinemethanamine
纯度： ≥99% (HPLC)
生物活性 for UCL 2077
UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker; reduces sAHP in hippocampal slice preparations. Displays no effect on Ca2+ currents or the time course of sAHP/sIAHP. Exhibits potent inhibition of KCNQ1 and KCNQ2, but differential effects at other KCNQs. Rescues memory retrieval in dopamine β-hydroxylase knockout mice.
技术数据 for UCL 2077
| 分子量 | 350.46 |
| 公式 | C25H22N2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 918311-87-2 |
| PubChem ID | 24868317 |
| InChI Key | PQFNWDHABGBCHB-UHFFFAOYSA-N |
| Smiles | C(NC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)C1=CN=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for UCL 2077
参考文献 for UCL 2077
参考文献是支持产品生物活性的出版物。
Shah et al (2006) Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol.Pharmacol. 70 1494 PMID: 16877678
Zhang et al (2013) The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval. J.Neurosci. 33 5006 PMID: 23486971
Soh and Tzingounis (2010) The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol.Pharmacol. 78 1088 PMID: 20843955
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关键词: UCL 2077, UCL 2077 supplier, Slow, hyperpolarization, sAHP, channels, blockers, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, UCL2077, Ca2+-Activated, Voltage-Gated, 2661, Tocris Bioscience
2 篇 UCL 2077 的引用文献
引用文献是使用了 Tocris 产品的出版物。 UCL 2077 的部分引用包括：
Zhang et al (2013) The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval. J Neurosci 33 5006 PMID: 23486971
Paz et al (2018) Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac. Neuropharmacology 137 309 PMID: 29758221
UCL 2077 的评论
平均评分: 5 (Based on 1 Review.)
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UCL 2077 in BK channel study.
By
Anonymous on 12/03/2018
分析类型： In Vitro
种属： Human
UCL 2077 has been used in our lab for assessing its blocking capacity in BK channels. the results were reliable and reproducible. Great product and will purchase again.
