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Submit ReviewUK 14,304
说明： α2 agonist
化学名： 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline
生物活性 for UK 14,304
UK 14,304 is a full α2 adrenergic agonist. Centrally active following systemic administration in vivo.
Water-soluble Salt also available.
化合物库 for UK 14,304
UK 14,304 is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for UK 14,304
| 分子量 | 292.14 |
| 公式 | C11H10BrN5 |
| 储存 | Store at RT |
| CAS Number | 59803-98-4 |
| PubChem ID | 2435 |
| InChI Key | XYLJNLCSTIOKRM-UHFFFAOYSA-N |
| Smiles | BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for UK 14,304
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 100 |
制备储备液 for UK 14,304
以下数据基于产品分子量 292.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.42 mL | 17.12 mL | 34.23 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.85 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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产品说明书 for UK 14,304
参考文献 for UK 14,304
参考文献是支持产品生物活性的出版物。
Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634
Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591
Macdonald et al (1997) Gene targeting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000
If you know of a relevant reference for UK 14,304, please let us know.
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关键词: UK 14,304, UK 14,304 supplier, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, agonists, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, UK14304, Adrenergic, Alpha-2, 0425, Tocris Bioscience
4 篇 UK 14,304 的引用文献
引用文献是使用了 Tocris 产品的出版物。 UK 14,304 的部分引用包括：
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Neurosci 336 127 PMID: 20959363
Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to mor. in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029 PMID: 11805341
Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapen. in rat single locus coeruleus neurons. J Pharmacol Exp Ther 172 460 PMID: 24372103
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
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