UK 14,304

Pricing Availability   Qty
说明: α2 agonist
化学名: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline
说明书
引用文献 (4)
评论
文献 (2)

生物活性 for UK 14,304

UK 14,304 is a full α2 adrenergic agonist. Centrally active following systemic administration in vivo.

Water-soluble Salt also available.

化合物库 for UK 14,304

UK 14,304 is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for UK 14,304

分子量 292.14
公式 C11H10BrN5
储存 Store at RT
CAS Number 59803-98-4
PubChem ID 2435
InChI Key XYLJNLCSTIOKRM-UHFFFAOYSA-N
Smiles BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for UK 14,304

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100

制备储备液 for UK 14,304

以下数据基于产品分子量 292.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.12 mL 34.23 mL
5 mM 0.68 mL 3.42 mL 6.85 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for UK 14,304

参考文献是支持产品生物活性的出版物。

Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634

Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591

Macdonald et al (1997) Gene targeting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000


If you know of a relevant reference for UK 14,304, please let us know.

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关键词: UK 14,304, UK 14,304 supplier, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, agonists, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, UK14304, Adrenergic, Alpha-2, 0425, Tocris Bioscience

4 篇 UK 14,304 的引用文献

引用文献是使用了 Tocris 产品的出版物。 UK 14,304 的部分引用包括:

Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to mor. in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029 PMID: 11805341

Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Neurosci 336 127 PMID: 20959363

Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapen. in rat single locus coeruleus neurons. J Pharmacol Exp Ther 172 460 PMID: 24372103


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