UK 78282 hydrochloride

Name: UK 78282 hydrochloride
Brand: Tocris Bioscience
SKU: 3829
Rating: 5 (1 reviews)

Cat. No. 3829 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Blocker of K_V1.3 and K_V1.4 channels

化学名： 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for UK 78282 hydrochloride

UK 78282 hydrochloride is a blocker of the K_V1.3 and K_V1.4 voltage-gated potassium channels in T lymphocytes (IC₅₀ values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks K_V1.4 expressed in heart and brain.

技术数据 for UK 78282 hydrochloride

分子量	466.05
公式	C₂₉H₃₅NO₂.HCl
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	136647-02-4
PubChem ID	53393337
InChI Key	ZZSQARULZYQMIG-UHFFFAOYSA-N
Smiles	COC(C=C3)=CC=C3CCCN1CCC(COC(C4=CC=CC=C4)C2=CC=CC=C2)CC1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for UK 78282 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	23.3	50
	ethanol	13.98	30

制备储备液 for UK 78282 hydrochloride

以下数据基于产品分子量 466.05。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.29 mL	21.46 mL	42.91 mL
2.5 mM	0.86 mL	4.29 mL	8.58 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

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产品说明书 for UK 78282 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for UK 78282 hydrochloride

参考文献是支持产品生物活性的出版物。

Hanson et al (1999) UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br.J.Pharmacol. 126 1707 PMID: 10372812

Chandy et al (2001) Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 39 1269 PMID: 11384714

Chandy et al (2004) K⁺ channels as targets for specific immunomodulation. Trends.Pharmacol.Sci. 25 280 PMID: 15120495

If you know of a relevant reference for UK 78282 hydrochloride, please let us know.

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