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说明： Potent inhibitor of L3MBTL3 Kme reader domain; cell permeable
化学名： 2-Phenylamino-1,4-[4-(pyrrolidinyl)piperidinyl)benzamide
纯度： ≥99% (HPLC)
生物活性 for UNC 1215
UNC 1215 is a potent inhibitor of L3MBTL3 methyllysine (Kme) reader domain (IC50 = 40 nM; Kd = 120 nM). Displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors. Disrupts subnuclear localization and foci formation of fluorescently-labeled L3MBTL3 in HEK293 cells.
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1215 probe summary on the SGC website.
External Portal Information for UNC 1215
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 1215 is reviewed on the chemical probes website.
技术数据 for UNC 1215
| 分子量 | 529.72 |
| 公式 | C32H43N5O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| PubChem ID | 57339144 |
| InChI Key | PQOOIERVZAXHBP-UHFFFAOYSA-N |
| Smiles | O=C(N2CCC(N3CCCC3)CC2)C1=C(NC6=CC=CC=C6)C=C(C(N4CCC(N5CCCC5)CC4)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for UNC 1215
参考文献 for UNC 1215
参考文献是支持产品生物活性的出版物。
James et al (2013) Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat.Chem.Biol. [Epub ahead of print] PMID: 23292653
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关键词: UNC 1215, UNC 1215 supplier, UNC1215, MBT, L3MBTL3, domain, epigenetics, readers, inhibitors, inhibits, selective, potent, in, vitro, sgc, Domains, 4666, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.