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UNC 8732

Cat. No. 8118 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent NSD2 Degrader
化学名： N-[[4-[[[2-(6-Amino-1-oxohexyl)-1,2,3,4-tetrahydro-6-isoquinolinyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-7-carboxamide trifluoroacetate
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for UNC 8732

UNC 8732 is a potent nuclear receptor binding SET domain-containing 2 (NSD2) Degrader (DC50 = 60 nM; Dmax = 97%). NSD2 degradation is driven by the aldehyde metabolite of UNC 8732 in vitro. Recruits FBX022 and SCF complexes for degradation to reduce H3K36me2 levels in cells. Reduces viability and restores glucocorticoid sensitivity of NSD2 p.E1099K mutant ALL cells.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC8732 page on the SGC website.

技术数据 for UNC 8732

分子量 723.75
公式 C35H39N5O5.CF3CO2H
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2929304-06-1
InChI Key HFQMCVDNCFEJSF-UHFFFAOYSA-N
Smiles O=C(C1=CC=C(CN(C2CC2)C(C3=CC=C4NC(COC4=C3)=O)=O)C=C1)NC5=CC=C6C(CCN(C6)C(CCCCCN)=O)=C5.OC(C(F)(F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for UNC 8732

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 72.37 100
ethanol 72.37 100

制备储备液 for UNC 8732

以下数据基于产品分子量 723.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.38 mL 6.91 mL 13.82 mL
5 mM 0.28 mL 1.38 mL 2.76 mL
10 mM 0.14 mL 0.69 mL 1.38 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for UNC 8732

参考文献是支持产品生物活性的出版物。

If you know of a relevant reference for UNC 8732, please let us know.

按标靶查看相关产品

关键词: UNC 8732, UNC 8732 supplier, UNC8732, E3, ligase, degrader, degrades, degraders, NSD2, nuclear, receptor, binding, SET, domain-containing, 2, potent, selective, Other, Degraders, 8118, Tocris Bioscience

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia