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说明： Positive allosteric modulator of AMPA receptors
化学名： N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
纯度： ≥98% (HPLC)
生物活性 for UoS 12258
UoS 12258 is a positive allosteric modulator of AMPA receptors (pEC50 = 5.2 for potentiation of AMPA-mediated currents in vitro). Also potentiates AMPA-mediated synaptic responses in vivo. Improves performance of rats in various learning and memory paradigms
化合物库 for UoS 12258
UoS 12258 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for UoS 12258
| 分子量 | 334.41 |
| 公式 | C17H19FN2O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 875927-64-3 |
| PubChem ID | 46398805 |
| InChI Key | QXQSUBKWSHMXDP-INIZCTEOSA-N |
| Smiles | CC(S(=O)(N[C@H]1CC2=CC=C(C3=CN=C(C=C3)F)C=C2C1)=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for UoS 12258
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.44 | 100 |
制备储备液 for UoS 12258
以下数据基于产品分子量 334.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.99 mL | 14.95 mL | 29.9 mL |
| 5 mM | 0.6 mL | 2.99 mL | 5.98 mL |
| 10 mM | 0.3 mL | 1.5 mL | 2.99 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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产品说明书 for UoS 12258
参考文献 for UoS 12258
参考文献是支持产品生物活性的出版物。
Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID: 20614889
Ward et al (2017) Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. Br.J.Pharmacol. 174 370 PMID: 28009436
If you know of a relevant reference for UoS 12258, please let us know.
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关键词: UoS 12258, UoS 12258 supplier, UoS12258, AMPA, receptors, PAM, postive, allosteric, modulators, modulates, cognitive, enhancer, Receptors, 6353, Tocris Bioscience
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