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Submit ReviewUPF 1069
说明： PARP-2 inhibitor
化学名： 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
纯度： ≥99% (HPLC)
生物活性 for UPF 1069
Selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).
技术数据 for UPF 1069
| 分子量 | 279.29 |
| 公式 | C17H13NO3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1048371-03-4 |
| PubChem ID | 25015515 |
| InChI Key | JJWMRRNGWSITSQ-UHFFFAOYSA-N |
| Smiles | O=C2NC=CC1=C(OCC(C3=CC=CC=C3)=O)C=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for UPF 1069
参考文献 for UPF 1069
参考文献是支持产品生物活性的出版物。
Moroni et al (2009) Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br.J.Pharmacol. 157 854 PMID: 19422384
Pellicciari et al (2008) On the way to selective PARP-2 inhibitors. Design, synthesis and preliminary evaluation of a series of isoquinolinone derivatives. Chem.Med.Chem 3 914
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关键词: UPF 1069, UPF 1069 supplier, PARP2, poly(ADP-ribose), polymerases, inhibitors, inhibits, UPF1069, Poly(ADP-ribose), Polymerase, 3736, Tocris Bioscience
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
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- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.