Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewuPSEM 817 tartrate
说明： Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
化学名： 2-Propoxy-7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline L-tartrate
纯度： ≥98% (HPLC)
生物活性 for uPSEM 817 tartrate
uPSEM 817 tartrate is a selective ultrapotent PSEM (uPSEM) agonist for α7L131G,Q139L,Y217F-GlyR (PSAM4-GlyR) and PSAM4-5-HT3 chimeric ion channels (EC50 values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical neurons expressing PSAM4-GlyR in brain slices. Increases contralateral rotation in mice expressing PSAM4-GlyR unilaterally in the substantia nigra reticulata (LED 0.1 mg/kg).
许可信息
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
技术数据 for uPSEM 817 tartrate
| 分子量 | 419.43 |
| 公式 | C16H19N3O.C4H6O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2341833-14-3 |
| Smiles | CCCOC1=NC2=C(N=C1)C=C(C3=C2)C4CNCC3C4.O[C@@H](C(O)=O)[C@@H](O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for uPSEM 817 tartrate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 41.94 | 100 | |
| water | 8.39 | 20 |
制备储备液 for uPSEM 817 tartrate
以下数据基于产品分子量 419.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.92 mL | 23.84 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for uPSEM 817 tartrate
参考文献 for uPSEM 817 tartrate
参考文献是支持产品生物活性的出版物。
Magnus et al (2019) Ultrapotent chemogenetics for research and potential clinical applications. Science 364 PMID: 30872534
If you know of a relevant reference for uPSEM 817 tartrate, please let us know.
关键词: uPSEM 817 tartrate, uPSEM 817 tartrate supplier, uPSEM817, tartrate, highly, potent, selective, α, alpha7L131G,Q139L,Y217F-GlyR, PSAM4-GlyR, agonists, agonism, PSEM, chemogenetics, PSEMs, Glycine, Receptors, 5-HT3, 6866, Tocris Bioscience
篇 uPSEM 817 tartrate 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 uPSEM 817 tartrate 的引用文献。 您是否知道使用了 Tocris uPSEM 817 tartrate 的优秀论文？ 请告知我们.
uPSEM 817 tartrate 的评论
目前没有该产品的评论。 Be the first to review uPSEM 817 tartrate and earn rewards!
Have you used uPSEM 817 tartrate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.