URB 597

Cat. No. 4612 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective FAAH inhibitor

化学名： Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester

纯度： ≥99% (HPLC)

引用文献 (6)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for URB 597

URB 597 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC₅₀ values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.

技术数据 for URB 597

分子量	338.4
公式	C₂₀H₂₂N₂O₃
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	546141-08-6
PubChem ID	1383884
InChI Key	ROFVXGGUISEHAM-UHFFFAOYSA-N
Smiles	NC(C1=CC(C2=CC=CC(OC(NC3CCCCC3)=O)=C2)=CC=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for URB 597

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	16.92	50

制备储备液 for URB 597

以下数据基于产品分子量 338.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.91 mL	29.55 mL	59.1 mL
2.5 mM	1.18 mL	5.91 mL	11.82 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
25 mM	0.12 mL	0.59 mL	1.18 mL

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产品说明书 for URB 597

分析证书/产品说明书

化学品安全技术说明书

参考文献 for URB 597

参考文献是支持产品生物活性的出版物。

Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435 1108 PMID: 15973410

Piomelli et al (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 12 21 PMID: 16834756

Jayamanne et al (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 147 281 PMID: 16331291

If you know of a relevant reference for URB 597, please let us know.

按标靶查看相关产品

关键词: URB 597, URB 597 supplier, URB597, faah, fatty, acid, amide, hydrolase, inhibitors, inhibits, selective, potent, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4612, Tocris Bioscience

6 篇 URB 597 的引用文献

引用文献是使用了 Tocris 产品的出版物。 URB 597 的部分引用包括：

Marc V et al (2021) Neurexin1α differentially regulates synaptic efficacy within striatal circuits. Cell Rep 34 108773 PMID: 33626349

Sardinha et al (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm 2014 978678 PMID: 24803745

Butti et al (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain 135 3320 PMID: 23008234

Vilela et al (2015) Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. J Neurosci 2015 523418 PMID: 25999668

Hamtiaux et al (2012) The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. BMC Cancer 12 92 PMID: 22429826

Morena et al (2016) Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. Neuropharmacology 111 59 PMID: 27553121

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