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Submit ReviewUrocortin (human)
说明： Endogenous CRF agonist
纯度： ≥95% (HPLC)
生物活性 for Urocortin (human)
Urocortin (human) is an endogenous CRF agonist. Ki values are 0.4, 0.3 and 0.5 nM for hCRF1, rCRF2α and mCRF2β respectively.
许可信息
Sold with the permission of the SALK Institute
技术数据 for Urocortin (human)
| 分子量 | 4696.29 |
| 公式 | C204H337N63O64 |
| 序列 |
DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV (Modifications: Val-40 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 176591-49-4 |
| PubChem ID | 24868180 |
| InChI Key | BIIOOWPFSOAZSO-WODJFTBTSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Urocortin (human)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Urocortin (human)
参考文献 for Urocortin (human)
参考文献是支持产品生物活性的出版物。
Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312 PMID: 10816663
Reul and Holsboer (2002) Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr.Opin.Pharmacol. 2 23 PMID: 11786305
Skelton et al (2000) The neurobiology of urocortin. Regul.Pept. 93 85 PMID: 11033056
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关键词: Urocortin (human), Urocortin (human) supplier, Endogenous, CRF, agonists, Corticotropin-Releasing, Factor, Non-Selective, Receptors, Non-selective, 1604, Tocris Bioscience
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.