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Valinomycin

Cat. No. 3373 3 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective K+ ionophore
化学名： Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
纯度： ≥90% (HPLC)
说明书
引用文献 (3)
评论 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Valinomycin

Valinomycin is a selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes. Inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

技术数据 for Valinomycin

分子量 1111.32
公式 C54H90N6O18
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 2001-95-8
PubChem ID 3000706
InChI Key FCFNRCROJUBPLU-DNDCDFAISA-N
Smiles O=C([C@H](C)OC([C@@H]([C@@H](C)C)NC([C@H](OC([C@@H](NC([C@@H](O1)C)=O)[C@@H](C)C)=O)[C@@H](C)C)=O)=O)N[C@@H]([C@@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@@H](C(O[C@@H](C)C(N[C@@H]([C@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@H]([C@H](C)C)C1=O)=O)=O)=O)=O)[C@H](C)C)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Valinomycin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.78 25
ethanol 27.78 25

制备储备液 for Valinomycin

以下数据基于产品分子量 1111.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 3.6 mL 18 mL 35.99 mL
1.25 mM 0.72 mL 3.6 mL 7.2 mL
2.5 mM 0.36 mL 1.8 mL 3.6 mL
12.5 mM 0.07 mL 0.36 mL 0.72 mL

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产品说明书 for Valinomycin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Valinomycin

参考文献是支持产品生物活性的出版物。

Davidson and Berman (1985) Interaction of valinomycin and monovalent cations with the (Ca2+,Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum. J.Biol.Chem. 260 7325 PMID: 3158656

Abdalah et al (2006) Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci.Letts. 405 68

Rose and Jenkins (2007) The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes. Bioelectrochem. 70 387

If you know of a relevant reference for Valinomycin, please let us know.

按标靶查看相关产品

关键词: Valinomycin, Valinomycin supplier, Selective, K+, ionophores, Potassium, antibiotics, Ionophores, Antibiotics, 3373, Tocris Bioscience

3 篇 Valinomycin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Valinomycin 的部分引用包括：

MacDonald et al (2019) A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics. Commun Biol 2 258 PMID: 31312727

Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. J Cancer 11 e0154932 PMID: 27183222

Yin et al (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun 9 2815 PMID: 30022023

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Valinomycin 的评论

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The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound.
By Anonymous on 02/01/2020
分析类型： In Vitro
种属： Other

Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience

PMID: 27183222
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Valimomycin was used in oxidative phosphorylation studies.
By Jade Smith on 02/05/2019
种属： Human

Valimomycin was used in oxidative phosphorylation studies. Performed well and gives repeatable results.

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