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Valsartan

Cat. No. 4216 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity, selective AT1 antagonist
别名： CGP 48933
化学名： (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Valsartan

Valsartan is a high affinity AT1 receptor antagonist (Ki = 2.38 nM). Displays 30,000-fold selectivity over AT2 receptors. Inhibits angiotensin II-induced release of aldosterone in vitro. Orally active.

化合物库 for Valsartan

Valsartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Valsartan

分子量 435.52
公式 C24H29N5O3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 137862-53-4
PubChem ID 60846
InChI Key ACWBQPMHZXGDFX-QFIPXVFZSA-N
Smiles CC(C)[C@@H]([C@@](O)=O)N(C(CCCC)=O)CC(C=C3)=CC=C3C1=CC=CC=C1C2=NN=NN2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Valsartan

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.55 100

制备储备液 for Valsartan

以下数据基于产品分子量 435.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Valsartan

参考文献是支持产品生物活性的出版物。

Criscione et al (1993) Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype. Br.J.Pharmacol. 110 761 PMID: 8242249

Wexler et al (1996) Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J.Med.Chem. 39 625 PMID: 8576904

Hanafy et al (2008) Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers. Br.J.Pharmacol. 153 90 PMID: 17965735

If you know of a relevant reference for Valsartan, please let us know.

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关键词: Valsartan, Valsartan supplier, Valsartan, CGP48933, atII, receptors, atI, angiotensin1, angiotensinI, antagonists, selective, CGP, 48933, Angiotensin, AT1, Receptors, 4216, Tocris Bioscience

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