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Submit ReviewVandetanib
说明： Potent VEGFR-2 inhibitor, also inhibits EGFR and RET oncoproteins activity
化学名： N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
纯度： ≥98% (HPLC)
生物活性 for Vandetanib
Vandetanib is a potent VEGFR-2 inhibitor (IC50 = 0.04 μM), and inhibitor of EGFR (IC50 = 0.5 μM). Vandetanib potently inhibits (IC50 = 100 nM) RET oncoprotein activity in human thyroid cancer. Vandetanib displays anti-angiogenic properties in human nasopharyngeal carcinoma in mice model. Vandetanib is orally available and effective in vivo.
技术数据 for Vandetanib
| 分子量 | 475.36 |
| 公式 | C22H24BrFN4O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 443913-73-3 |
| PubChem ID | 3081361 |
| InChI Key | UHTHHESEBZOYNR-UHFFFAOYSA-N |
| Smiles | FC1=CC(Br)=CC=C1NC=2N=CN=C3C=C(OCC4CCN(C)CC4)C(OC)=CC32 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Vandetanib
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 23.77 | 50 |
制备储备液 for Vandetanib
以下数据基于产品分子量 475.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.21 mL | 21.04 mL | 42.07 mL |
| 2.5 mM | 0.84 mL | 4.21 mL | 8.41 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.21 mL |
| 25 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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产品说明书 for Vandetanib
参考文献 for Vandetanib
参考文献是支持产品生物活性的出版物。
Carlomagno et al (2002) ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer res. 62 7284 PMID: 12499271
Cui et al (2015) Resonance imaging for monitoring the early response to ZD6474 from nasopharyngeal carcinoma in nude mouse. Sci.Rep. 5 16389 PMID: 26574153
Ancker et al (2019) Multikinase inhibitor treatment in thyroid cancer. Int.J.Mol.Sci. 21 10 PMID: 31861373
Hennequin et al (2002) Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 45 1300 PMID: 11881999
If you know of a relevant reference for Vandetanib, please let us know.
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关键词: Vandetanib, Vandetanib supplier, Potent, inhibitors, inhibits, VEGFR-2, Vascular, Endothelial, Growth, Factors, Receptors, KDR, Flk1, EGFR, epidermal, growth, factor, receptor, anticancer, RET, VEGFR, 7497, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for Vandetanib
