Vatalanib succinate

Cat. No. 5680 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent VEGFR inhibitor; also aromatase inhibitor

别名： CGP 79787D,PTK787/ZK222584

化学名： N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate

纯度： ≥99% (HPLC)

引用文献 (2)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Vatalanib succinate

Vatalanib succinate is a potent VEGFR inhibitor (IC₅₀ values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs in vitro and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC₅₀ = 50 nM). Orally available.

技术数据 for Vatalanib succinate

分子量	464.9
公式	C₂₀H₁₅ClN₄.C₄H₆O₄
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	212142-18-2
PubChem ID	151193
InChI Key	LLDWLPRYLVPDTG-UHFFFAOYSA-N
Smiles	ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42.OC(CCC(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Vatalanib succinate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	46.49	100

制备储备液 for Vatalanib succinate

以下数据基于产品分子量 464.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.76 mL	21.51 mL
5 mM	0.43 mL	2.15 mL	4.3 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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产品说明书 for Vatalanib succinate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Vatalanib succinate

参考文献是支持产品生物活性的出版物。

Banerjee et al (2009) The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase. Cancer Res. 69 4716 PMID: 19435899

Wood et al (2000) PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60 2178 PMID: 10786682

Bold et al (2000) New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J.Med.Chem. 43 2310 PMID: 10956229

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关键词: Vatalanib succinate, Vatalanib succinate supplier, CGP79787D, PTK787, ZK222584, aromatase, inhibitors, inhibits, vascular, endothelial, growth, factor, receptors, tyrosine, kinases, cancer, anticancer, VEGFR, angiogenesis, metastasis, CGP, 79787D, PTK787/ZK222584, Cytochrome, P450, 5680, Tocris Bioscience

2 篇 Vatalanib succinate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Vatalanib succinate 的部分引用包括：

Rasmussen et al (2018) Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization. Dev Cell 46 344 PMID: 30032992

Jeffrey P et al (2022) Osteoblasts pattern endothelium and somatosensory axons during zebrafish caudal fin organogenesis. Development 149 PMID: 35129199

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Vatalanib succinate

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.