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Submit ReviewVDM 11
说明： Potent, selective anandamide transport inhibitor
化学名： (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide
纯度： ≥98% (HPLC)
生物活性 for VDM 11
A potent and selective inhibitor of the anandamide membrane transporter (AMT) with IC50 values of 4-11 μM. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB1 and CB2 receptors. Ki values are > 5-10 μM at CB1 and CB2. Active in vivo. Also available in water-soluble emulsion (Cat. No. 1686).
技术数据 for VDM 11
| 分子量 | 409.61 |
| 公式 | C27H39NO2 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 313998-81-1 |
| PubChem ID | 9887748 |
| InChI Key | WUZWFRWVRHLXHZ-ZKWNWVNESA-N |
| Smiles | O=C(NC1=C(C)C=C(O)C=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VDM 11
参考文献 for VDM 11
参考文献是支持产品生物活性的出版物。
Bisogno et al (2001) The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. Eur.J.Biochem. 268 1982 PMID: 11277920
De Petrocellis et al (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett. 483 52 PMID: 11033355
De Petrocellis et al (2001) The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J.Biol.Chem. 276 12856 PMID: 11278420
Gubellini et al (2002) Experimental Parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. J.Neurosci. 22 6900 PMID: 12177188
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关键词: VDM 11, VDM 11 supplier, Potent, selective, anandamide, transporters, inhibitors, inhibits, AMT, Cannabinoids, Monoamine, Neurotransmitter, VDM11, Cannabinoid, Transporters, 1392, Tocris Bioscience
5 篇 VDM 11 的引用文献
引用文献是使用了 Tocris 产品的出版物。 VDM 11 的部分引用包括：
Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129
Hillard et al (2007) Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. Br J Pharmacol 152 691 PMID: 17891162
Newman et al (2007) Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. Eur J Neurosci 25 1619 PMID: 17408433
Ronesi et al (2004) Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport. J Neurosci 24 1673 PMID: 14973237
Battista et al (2002) Anandamide uptake by synaptosomes from human, mouse and rat brain: inhibition by glutamine and glutamate. Cereb Cortex 1 1 PMID: 12617751
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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