Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVDM 11 (in Tocrisolve™ 100)
Description: Potent, selective anandamide transport inhibitor (in water-soluble emulsion)
Chemical Name: (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide
Biological Activity for VDM 11 (in Tocrisolve™ 100)
A potent and selective inhibitor of the anandamide membrane transporter (AMT), in water-soluble emulsion (for details see TocrisoveTM 100). IC50 values for inhibition of AMT are 4 - 11 mM. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB1 and CB2 receptors. Ki values are > 5 - 10 mM at CB1 and CB2. Active in vivo.
VDM 11, pure oil dissolved in ethanol and Tocrisolve Control also available.
Technical Data for VDM 11 (in Tocrisolve™ 100)
| M. Wt | 409.61 |
| Formula | C27H39NO2 |
| Storage | Store at +4°C |
| CAS Number | 313998-81-1 |
| PubChem ID | 9887748 |
| InChI Key | WUZWFRWVRHLXHZ-ZKWNWVNESA-N |
| Smiles | O=C(NC1=C(C)C=C(O)C=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VDM 11 (in Tocrisolve™ 100)
References for VDM 11 (in Tocrisolve™ 100)
References are publications that support the biological activity of the product.
Bisogno et al (2001) The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. Eur.J.Biochem. 268 1982 PMID: 11277920
De Petrocellis et al (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett. 483 52 PMID: 11033355
De Petrocellis et al (2001) The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J.Biol.Chem. 276 12856 PMID: 11278420
Gubellini et al (2002) Experimental Parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. J.Neurosci. 22 6900 PMID: 12177188
View Related Products by Target
View Related Products by Product Action
Keywords: VDM 11 (in Tocrisolve 100), VDM 11 (in Tocrisolve 100) supplier, Potent, selective, anandamide, transporters, inhibitors, inhibits, water-soluble, emulsion, AMT, Anandamide, cannabinoids, Monoamine, Neurotransmitter, VDM11, Tocrisolve100, Cannabinoid, Transporters, 1686, Tocris Bioscience
Citations for VDM 11 (in Tocrisolve™ 100)
Citations are publications that use Tocris products.
Currently there are no citations for VDM 11 (in Tocrisolve™ 100).
Reviews for VDM 11 (in Tocrisolve™ 100)
There are currently no reviews for this product. Be the first to review VDM 11 (in Tocrisolve™ 100) and earn rewards!
Have you used VDM 11 (in Tocrisolve™ 100)?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.