Venlafaxine hydrochloride

Cat. No. 2917 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： 5-HT and NA reuptake inhibitor (SNRI)

别名： Wy 45030

化学名： 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Venlafaxine hydrochloride

Venlafaxine hydrochloride is a dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (K_i values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.

化合物库 for Venlafaxine hydrochloride

Venlafaxine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Venlafaxine hydrochloride

分子量	313.86
公式	C₁₇H₂₇NO₂.HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	99300-78-4
PubChem ID	62923
InChI Key	QYRYFNHXARDNFZ-UHFFFAOYSA-N
Smiles	OC2(CCCCC2)C(CN(C)C)C1=CC=C(OC)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Venlafaxine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	31.39	100
	DMSO	15.69	50

制备储备液 for Venlafaxine hydrochloride

以下数据基于产品分子量 313.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.19 mL	15.93 mL	31.86 mL
5 mM	0.64 mL	3.19 mL	6.37 mL
10 mM	0.32 mL	1.59 mL	3.19 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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产品说明书 for Venlafaxine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Venlafaxine hydrochloride

参考文献是支持产品生物活性的出版物。

Magalas et al (2005) The serotonin/noradrenaline reuptake inhibitor venlaf. attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 528 103 PMID: 16325805

Gould et al (2006) A comparison of the chronic treatment effects of venlaf. and other antidepressants on serotonin and NE transporters. Biol.Psychiatry 59 408 PMID: 16140280

Bymaster et al (2001) Comparative affinity of dulox. and venlaf. for serotonin and NE transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 25 871 PMID: 11750180

If you know of a relevant reference for Venlafaxine hydrochloride, please let us know.

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关键词: Venlafaxine hydrochloride, Venlafaxine hydrochloride supplier, Dual, serotonin/noradrenaline, reuptake, inhibitors, inhibits, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, SERT, 5-HT, 5-Hydroxytryptamine, Wy45030, Wy, 45030, 2917, Tocris Bioscience

3 篇 Venlafaxine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Venlafaxine hydrochloride 的部分引用包括：

Stuart et al (2015) Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy. Proc Natl Acad Sci U S A 40 2165 PMID: 25740288

Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951

Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126

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