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VH 032 amide-alkylC5-azide

Cat. No. 7867 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： VHL ligand with alkylC5 linker and terminal azide for onward chemistry
化学名： (2S,4R)-1-((S)-2-(6-Azidohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度： ≥95% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for VH 032 amide-alkylC5-azide

VH 032 amide-alkylC5-azide is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC5 linker and terminal azide ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for VH 032 amide-alkylC5-azide

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for VH 032 amide-alkylC5-azide

分子量 569.73
公式 C28H39N7O4S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2821804-11-7
InChI Key FKUOHRQDBXOUQK-OTNCWRBYSA-N
Smiles O=C(CCCCCN=[N+]=[N-])N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for VH 032 amide-alkylC5-azide

分析证书/产品说明书
化学品安全技术说明书

参考文献 for VH 032 amide-alkylC5-azide

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia