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VH 032 amide-PEG2-alkyne

Cat. No. 6684 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6684 has been discontinued.

View all VHL Targeting Ligands Plus Linkers products.
说明： VHL ligand with PEG linker and terminal alkyne for onward chemistry
别名： (S,R,S)-AHPC-PEG2-Alkyne
化学名： (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度： ≥95% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for VH 032 amide-PEG2-alkyne

VH 032 amide-PEG2-alkyne is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus PEG2 linker with terminal alkyne ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 6

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for VH 032 amide-PEG2-alkyne

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for VH 032 amide-PEG2-alkyne

分子量 614.75
公式 C31H42N4O7S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2098799-80-3
PubChem ID 132045744
InChI Key HHXQNDSXTCIWSG-CERRFVOPSA-N
Smiles CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCC#C)=O)=O)O)=O)SC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for VH 032 amide-PEG2-alkyne

分析证书/产品说明书
化学品安全技术说明书

参考文献 for VH 032 amide-PEG2-alkyne

参考文献是支持产品生物活性的出版物。

Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 10 1770 PMID: 26035625

Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825

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关键词: VH 032 amide-PEG2-alkyne, VH 032 amide-PEG2-alkyne supplier, VH032, -, linker, 6, Proteolysis, Targeting, Chimera, PROTACs, VHL, E3, ubiquitin, ligase, PEG, conjugate, PROTAC, polyethene, glycol, von-Hippel-Lindau, protein, ligand, PEG2, (S,R,S)-AHPC-PEG2-Alkyne, Ligands, Plus, Linkers, 6684, Tocris Bioscience

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia