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Submit ReviewVH 032 amide-PEG3-amine
说明： VHL ligand with PEG linker and terminal amine for onward chemistry
别名： (S,R,S)-AHPC-PEG3-NH2
化学名： (2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
纯度： ≥95% (HPLC)
生物活性 for VH 032 amide-PEG3-amine
VH 032 amide-PEG3-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
This product has been recently renamed. The previous name for this product was VH 032 - linker 1
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for VH 032 amide-PEG3-amine
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据 for VH 032 amide-PEG3-amine
| 分子量 | 692.69 |
| 公式 | C30H45N5O7S.2HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2376990-24-6 |
| PubChem ID | 131704494 |
| InChI Key | JUGLITFMQVMQDY-SGROTYDGSA-N |
| Smiles | CC(C)(C)[C@@H](C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)NC(COCCOCCOCCN)=O.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VH 032 amide-PEG3-amine
参考文献 for VH 032 amide-PEG3-amine
参考文献是支持产品生物活性的出版物。
Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem. Biol. 10 1770 PMID: 26035625
Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825
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关键词: VH 032 amide-PEG3-amine, VH 032 amide-PEG3-amine supplier, Proteolysis, Targeting, Chimera, PROTACs, VHL, E3, ubiquitin, ligase, PEG, linker, conjugate, PROTAC, polyethene, glycol, von-Hippel-Lindau, protein, ligand, VH032, 1, 2097971-11-2, building, blocks, (S,R,S)-AHPC-PEG3-NH2, Ligands, Plus, Linkers, 6463, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia