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VH 032 amide-PEG3-BCN

Cat. No. 8123 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Functionalized VHL building block for copper-free click chemistry
化学名： ((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate
纯度： ≥90% (HPLC)
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生物活性 for VH 032 amide-PEG3-BCN

VH 032 amide-PEG3-BCN is a functionalized von Hippel Lindau (VHL) protein ligand for PROTAC® research and development. Incorporates an E3 ligase ligand plus a PEG3 linker with terminal bicyclooctyne (BCN). It can be used for copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for VH 032 amide-PEG3-BCN

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for VH 032 amide-PEG3-BCN

分子量 810.02
公式 C42H59N5O9S
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 2876198-36-4
PubChem ID 169450546
InChI Key WLQVZOBNMRIBKF-LLQRHEORSA-N
Smiles O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCOCCOCCNC(OC[C@H]4[C@]5([H])[C@@]4([H])CCC#CCC5)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for VH 032 amide-PEG3-BCN

分析证书/产品说明书
化学品安全技术说明书

参考文献 for VH 032 amide-PEG3-BCN

参考文献是支持产品生物活性的出版物。

Liu et al (2021) TF-PROTACs enable targeted degradation of transcription factors. J.Am.Chem.Soc. 143 8902 PMID: 34100597

If you know of a relevant reference for VH 032 amide-PEG3-BCN, please let us know.

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关键词: VH 032 amide-PEG3-BCN, VH 032 amide-PEG3-BCN supplier, PROTACs, degraders, component, VHL, von, Hippel, lindau, E3, ubiquitin, ligase, PEG3, linker, building, block, ligands, targeted, protein, degradation, TPD, BCN, copper, free, strain, promoted, azide, alkyne, cycloaddition, SPAAC, Ligands, Plus, Linkers, 8123, Tocris Bioscience

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia