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VH 101 phenol-alkylC6-amine

Cat. No. 7294 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： VHL ligand with alkyl linker and terminal amine for onward chemistry
化学名： (2S,4R)-N-(2-((6-Aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
纯度： ≥95% (HPLC)
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生物活性 for VH 101 phenol-alkylC6-amine

VH 101 phenol-alkylC6-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC6 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

许可信息

Sold under licence from the University of Dundee.

Usage guidelines for VH 101 phenol-alkylC6-amine

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for VH 101 phenol-alkylC6-amine

分子量 704.72
公式 C32H46FN5O5S.2HCl
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2564467-16-7
InChI Key BKJRFJDVCDFVCY-SGROTYDGSA-N
Smiles CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C4(CC4)F)=O)C(C)(C)C)=O)=O)C(OCCCCCCN)=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for VH 101 phenol-alkylC6-amine

分析证书/产品说明书
化学品安全技术说明书

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia