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Submit ReviewVilazodone hydrochloride
说明： Potent 5-HT1A partial agonist and SSRI; antidepressant
别名： EMD 68843,SB 659746A
化学名： 5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Vilazodone hydrochloride
Vilazodone hydrochloride is a potent 5-HT1A partial agonist and serotonin-selective reuptake inhibitor (SSRI) (IC50 values are 0.2 and 0.5 nM respectively). Antidepressant.
化合物库 for Vilazodone hydrochloride
Vilazodone hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Vilazodone hydrochloride
| 分子量 | 477.99 |
| 公式 | C26H27N5O2.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 163521-08-2 |
| PubChem ID | 6918313 |
| InChI Key | RPZBRGFNBNQSOP-UHFFFAOYSA-N |
| Smiles | NC(C1=CC2=C(C=CC(N3CCN(CC3)CCCCC4=CNC5=C4C=C(C#N)C=C5)=C2)O1)=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Vilazodone hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 9.56 | 20 |
制备储备液 for Vilazodone hydrochloride
以下数据基于产品分子量 477.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.46 mL | 52.3 mL | 104.6 mL |
| 1 mM | 2.09 mL | 10.46 mL | 20.92 mL |
| 2 mM | 1.05 mL | 5.23 mL | 10.46 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.09 mL |
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产品说明书 for Vilazodone hydrochloride
参考文献 for Vilazodone hydrochloride
参考文献是支持产品生物活性的出版物。
Hughes et al (2005) Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. Eur.J.Pharmacol. 510 49 PMID: 15740724
If you know of a relevant reference for Vilazodone hydrochloride, please let us know.
按产品操作查看相关产品
关键词: Vilazodone hydrochloride, Vilazodone hydrochloride supplier, SB659746A, EMD68843, Potent, 5-HT1A, partial, agonists, agonism, serotonin-selective, reuptake, inhibitors, inhibits, SSRI, antidepressant, depression, EMD, 68843, SB, 659746A, Receptors, 5-HT, Transporters, 6202, Tocris Bioscience
1 篇 Vilazodone hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Vilazodone hydrochloride 的部分引用包括：
Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.