VU 0155069

Cat. No. 3575 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective PLD1 inhibitor

化学名： N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for VU 0155069

VU 0155069 is a potent and selective phospholipase D1 (PLD1) inhibitor (IC₅₀ values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.

化合物库 for VU 0155069

VU 0155069 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for VU 0155069

分子量	499.43
公式	C₂₆H₂₇ClN₄O₂.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1781834-89-6
PubChem ID	56972237
InChI Key	RQULTQQAHGYYDG-LMOVPXPDSA-N
Smiles	O=C(N[C@@H](C)CN3CCC(N5C4=C(NC5=O)C=C(Cl)C=C4)CC3)C(C=C2)=CC1=C2C=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 0155069

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	49.94	100
	ethanol	24.97	50

制备储备液 for VU 0155069

以下数据基于产品分子量 499.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2 mL	10.01 mL	20.02 mL
5 mM	0.4 mL	2 mL	4 mL
10 mM	0.2 mL	1 mL	2 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for VU 0155069

分析证书/产品说明书

化学品安全技术说明书

参考文献 for VU 0155069

参考文献是支持产品生物活性的出版物。

Scott et al (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat.Chem.Biol. 5 108 PMID: 19136975

Lewis et al (2009) Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg.Med.Chem.Lett. 19 1916 PMID: 19268584

If you know of a relevant reference for VU 0155069, please let us know.

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关键词: VU 0155069, VU 0155069 supplier, VU0155069, PLD1, phospholipases, D, specific, inhibitors, inhibits, potent, selective, esterases, Phospholipases, 3575, Tocris Bioscience