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说明： Selective positive allosteric modulator of M5 receptors
化学名： 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin
纯度： ≥97% (HPLC)
生物活性 for VU 0238429
VU 0238429 is a selective positive allosteric modulator of M5 receptors (EC50 values are 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively). Displays no activity at M2 and M4 receptors.
化合物库 for VU 0238429
VU 0238429 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for VU 0238429
| 分子量 | 351.28 |
| 公式 | C17H12F3NO4 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1160247-92-6 |
| PubChem ID | 42633508 |
| InChI Key | CKLGZXFOLMHCMC-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(OC)C=C3)C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0238429
参考文献 for VU 0238429
参考文献是支持产品生物活性的出版物。
Bridges et al (2009) Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J.Med.Chem. 52 3445 PMID: 19438238
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关键词: VU 0238429, VU 0238429 supplier, Selective, positive, allosteric, modulators, PAMs, M5, receptors, Muscarinic, Acetylcholine, Ach, VU0238429, Receptors, 3634, Tocris Bioscience
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