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Submit ReviewVU 0360172 hydrochloride
说明： Positive allosteric modulator of mGlu5 receptors
化学名： N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for VU 0360172 hydrochloride
VU 0360172 hydrochloride is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.
化合物库 for VU 0360172 hydrochloride
VU 0360172 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for VU 0360172 hydrochloride
| 分子量 | 330.78 |
| 公式 | C18H15FN2O.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1309976-62-2 |
| PubChem ID | 53384852 |
| InChI Key | NBGAPTWZQXSEAA-UHFFFAOYSA-N |
| Smiles | FC1=CC=CC(C#CC2=CC=C(C(NC3CCC3)=O)C=N2)=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for VU 0360172 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 16.54 | 50 | |
| ethanol | 8.27 | 25 |
制备储备液 for VU 0360172 hydrochloride
以下数据基于产品分子量 330.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.05 mL | 30.23 mL | 60.46 mL |
| 2.5 mM | 1.21 mL | 6.05 mL | 12.09 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.05 mL |
| 25 mM | 0.12 mL | 0.6 mL | 1.21 mL |
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产品说明书 for VU 0360172 hydrochloride
参考文献 for VU 0360172 hydrochloride
参考文献是支持产品生物活性的出版物。
Rodriguez et al (2010) Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol.Pharmacol. 78 1105 PMID: 20923853
D'Amore et al (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology 66 330 PMID: 22705340
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关键词: VU 0360172 hydrochloride, VU 0360172 hydrochloride supplier, VU0360172, hydrochloride, Positive, allosteric, modulators, mGlu5, mGluR5, mGlur, Group, I, Receptors, Glutamate, Metabotropic, antipsychotic, absence, epilepsy, PAM, (Metabotropic), 4323, Tocris Bioscience
2 篇 VU 0360172 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 VU 0360172 hydrochloride 的部分引用包括：
Hanak et al (2019) Positive modulation of mGluR5 attenuates seizures and reduces TNF-α+ macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy. Exp.Neurol. 311 194 PMID: 30316834
Bogdan A et al (2021) Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice. J Neurochem 156 225-248 PMID: 31926033
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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