VU 0364739 hydrochloride

Cat. No. 4171 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective PLD2 inhibitor

化学名： N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide

纯度： ≥98% (HPLC)

引用文献 (10)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for VU 0364739 hydrochloride

VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC₅₀ = 20 nM); displays 75-fold selectivity against PLD1 (IC₅₀ = 1500 nM).

化合物库 for VU 0364739 hydrochloride

VU 0364739 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for VU 0364739 hydrochloride

分子量	482.98
公式	C₂₆H₂₇FN₄O₂.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1244640-48-9
PubChem ID	46939225
InChI Key	RYLAMDMOILNBKN-UHFFFAOYSA-N
Smiles	O=C(NCCN3CCC(C(NCN4C5=CC(F)=CC=C5)=O)4CC3)C2=CC1=CC=CC=C1C=C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 0364739 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	48.3	100

制备储备液 for VU 0364739 hydrochloride

以下数据基于产品分子量 482.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.35 mL	20.7 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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产品说明书 for VU 0364739 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for VU 0364739 hydrochloride

参考文献是支持产品生物活性的出版物。

Lavieri et al (2010) Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J.Med.Chem. 53 6709

If you know of a relevant reference for VU 0364739 hydrochloride, please let us know.

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