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Submit ReviewVU 0409106
Discontinued Product
5322 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Potent and selective negative allosteric modulator of mGlu5 receptors
化学名： 3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide
纯度： ≥98% (HPLC)
生物活性 for VU 0409106
VU 0409106 is a potent and selective mGlu5 negative allosteric modulator (IC50 = 49 nM at human mGlu5). Selective for mGlu5 over a panel of GPCRs and ion channels. Exhibits no significant nonspecific binding in rat brain homogenates in vitro. Inhibits marble burying behavior in mice. Brain penetrant.
化合物库 for VU 0409106
VU 0409106 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for VU 0409106
| 分子量 | 330.34 |
| 公式 | C15H11FN4O2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1276617-62-9 |
| PubChem ID | 50990953 |
| InChI Key | AXVLPJHYYFHCHK-UHFFFAOYSA-N |
| Smiles | FC1=CC(OC2=CN=CN=C2)=CC(C(NC3=NC(C)=CS3)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0409106
参考文献 for VU 0409106
参考文献是支持产品生物活性的出版物。
Felts et al (2013) Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorg.Med.Chem.Lett. 23 5779 PMID: 24074843
关键词: VU 0409106, VU 0409106 supplier, VU0409106, metabotropic, glutamate, receptors, negative, allosteric, modulators, NAMs, mGluR5, class, I, Glutamate, (Metabotropic), Group, Receptors, 5322, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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