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VU 0546110

Cat. No. 7956 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective SLO3 potassium channel inhibitor
化学名： 1-[4-[[(4-Methoxyphenyl)thio]methyl]-1-piperidinyl]-2-[4-[(1-methylethyl)sulfonyl]phenyl]ethanone
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for VU 0546110

VU 0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3 (IC50 = 64 μM). It shows 40-fold selectivity over SLO1. It completely blocks heterologous SLO3 currents and endogenous K+ currents. VU 0546110 inhibits sperm hyperpolarisation and prevents its hyperactivated mobility.

技术数据 for VU 0546110

分子量 461.64
公式 C24H31NO4S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1421523-00-3
PubChem ID 71800954
InChI Key IUFAHCWQEABYHO-UHFFFAOYSA-N
Smiles O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 0546110

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.16 100
ethanol 23.08 50

制备储备液 for VU 0546110

以下数据基于产品分子量 461.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.66 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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参考文献 for VU 0546110

参考文献是支持产品生物活性的出版物。

Lyon et al (2023) A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function. Proc.Natl.Acad.Sci.U.S.A. 120 e2212338120 PMID: 36649421

If you know of a relevant reference for VU 0546110, please let us know.

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关键词: VU 0546110, VU 0546110 supplier, VU0546110, selective, potassium, channels, K+, currents, slo, channel, hyperpolarisation, Non-selective, /, Other, Potassium, Channels, 7956, Tocris Bioscience

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