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VU 152100

Cat. No. 3383 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Positive allosteric modulator of M4 receptors
别名： ML 108
化学名： 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for VU 152100

VU 152100 is a selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM). Induces 21-fold shift in ACh potency at M4 receptor. Displays no activity at other mAChR subtypes.

化合物库 for VU 152100

VU 152100 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for VU 152100

分子量 341.43
公式 C18H19N3O2S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 409351-28-6
PubChem ID 864492
InChI Key MDNWGCQSCGNTKH-UHFFFAOYSA-N
Smiles CC1=C2C(SC(C(NCC3=CC=C(OC)C=C3)=O)=C2N)=NC(C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 152100

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.07 50

制备储备液 for VU 152100

以下数据基于产品分子量 341.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.86 mL 29.29 mL 58.58 mL
2.5 mM 1.17 mL 5.86 mL 11.72 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
25 mM 0.12 mL 0.59 mL 1.17 mL

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产品说明书 for VU 152100

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for VU 152100

参考文献是支持产品生物活性的出版物。

Brady et al (2008) Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 327 941 PMID: 18772318

If you know of a relevant reference for VU 152100, please let us know.

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关键词: VU 152100, VU 152100 supplier, muscarinic, receptors, mAChR, M4, acetylcholine, ACh, selective, positive, allosteric, modulators, VU152100, PAM, ML, 108, ML_108, ML108, Receptors, 3383, Tocris Bioscience

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