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VU 6015929

Cat. No. 7728 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective discoidin domain receptor 1/2 inhibitor
化学名： 4-Fluoro-3-[[[5-(1-methyl-1H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for VU 6015929

VU 6015929 is a potent and selective discoidin domain receptor 1/2 (DDR1/2) inhibitor (IC50 = 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively). VU 6015929 blocks collagen-induced DDR1 activation and collagen-IV production in HEK293 cells.

技术数据 for VU 6015929

分子量 485.43
公式 C24H19F4N5O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2442597-56-8
PubChem ID 145925694
InChI Key IZKVIUJIUTXIRH-UHFFFAOYSA-N
Smiles O=C(NC=1C=CC=C(OC(F)(F)F)C1)C2=CC=C(F)C(=C2)NCC3=CN=CC(=C3)C4=NN(C=C4)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 6015929

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 48.54 100
ethanol 9.71 20

制备储备液 for VU 6015929

以下数据基于产品分子量 485.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.3 mL 20.6 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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参考文献 for VU 6015929

参考文献是支持产品生物活性的出版物。

Sun (2021) Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion. Nature 599 673 PMID: 34732895

Jeffries et al (2019) Discovery of VU6015929: a selective discoidin domain receptor 1/2 (DDR1/2) inhibitor to explore the role of DDR1 in antifibrotic therapy. ACS Med.Chem.Lett. 11 29 PMID: 31938459

If you know of a relevant reference for VU 6015929, please let us know.

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关键词: VU 6015929, VU 6015929 supplier, VU6015929, potent, selective, discoidin, domain, receptor, 1, 2, DDR1, DDR2, inhibitor, inhibits, collagen, IV, production, Other, RTKs, 7728, Tocris Bioscience

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