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Submit ReviewVUF 10166
说明： High affinity 5-HT3 antagonist
化学名： 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline
纯度： ≥98% (HPLC)
生物活性 for VUF 10166
VUF 10166 is a high affinity 5-HT3 receptor antagonist (IC50 values are 0.04 and 22 nM for human 5HT3A and 5-HT3AB receptors respectively). Exhibits partial agonist activity at 5-HT3A receptors at higher concentrations (EC50 = 5.2 μM). Also histamine H4 receptor antagonist (pKi = 6.64 in HEK cells).
技术数据 for VUF 10166
| 分子量 | 262.74 |
| 公式 | C13H15ClN4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 155584-74-0 |
| PubChem ID | 24278976 |
| InChI Key | FFXVTQDGTKEXHF-UHFFFAOYSA-N |
| Smiles | ClC2=NC1=CC=CC=C1N=C2N3CCN(C)CC3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VUF 10166
参考文献 for VUF 10166
参考文献是支持产品生物活性的出版物。
Thompson et al (2012) VUF10166, a novel compound with differing activities at 5-HT3A and 5-HT3AB receptors. J.Pharmacol.Exp.Ther. 341 350 PMID: 22306960
Smits et al (2008) Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J.Med.Chem. 51 2457 PMID: 18357976
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关键词: VUF 10166, VUF 10166 supplier, 5-ht, serotonin, receptors, antagonists, high, affinity, partial, agonists, 5-ht3a, 5-ht3ab, 5-ht3, 5ht, VUF10166, 5-HT3, Receptors, 4532, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.