主页 / 药理学 / GPCRs / 7-TM Receptors / Adenosine Receptors / Adenosine A3 Receptors / Adenosine A3 Receptor Antagonists / VUF 5574

VUF 5574

Cat. No. 1359 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1359 has been discontinued.

View all Adenosine A<sub>3</sub> Receptors products.
说明： Potent, selective hA3 antagonist
化学名： N-(2-Methoxyphenyl)-N'-[2-(3-pyrindinyl)-4-quinazolinyl]-urea
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for VUF 5574

VUF 5574 is a potent, selective, competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM). Displays ≥ 2500-fold selectivity over A1 and A2A receptors.

技术数据 for VUF 5574

分子量 371.39
公式 C21H17N5O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 280570-45-8
PubChem ID 4046493
InChI Key YRAFEJSZTVWUMD-UHFFFAOYSA-N
Smiles O=C(NC2=NC(C4=CC=CN=C4)=NC3=C2C=CC=C3)NC1=C(OC)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for VUF 5574

参考文献是支持产品生物活性的出版物。

Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456 PMID: 11121831

van Muijlwijk-Koezen et al (2000) Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor. J.Med.Chem. 43 2227 PMID: 10841801

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Adenosine A3 Receptor Antagonists

关键词: VUF 5574, VUF 5574 supplier, Potent, selective, hA3, antagonists, Receptors, adenosines, VUF5574, Adenosine, A3, 1359, Tocris Bioscience

2 篇 VUF 5574 的引用文献

引用文献是使用了 Tocris 产品的出版物。 VUF 5574 的部分引用包括：

Hua et al (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One 6 e24947 PMID: 21966389

Pugliese et al (2006) A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro. Br J Pharmacol 147 524 PMID: 16415905

VUF 5574 的评论

目前没有该产品的评论。 Be the first to review VUF 5574 and earn rewards!

Have you used VUF 5574?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review