W-13 hydrochloride

Name: W-13 hydrochloride
Brand: Tocris Bioscience
SKU: 0361
Rating: 5 (1 reviews)

Cat. No. 0361 2 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0361 has been discontinued.

View all Calcium Binding Proteins products.

说明： Calmodulin antagonist

化学名： N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for W-13 hydrochloride

W-13 hydrochloride is a calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC₅₀ of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.

技术数据 for W-13 hydrochloride

分子量	349.27
公式	C₁₄H₁₇ClN₂O₂S.HCl
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	88519-57-7
PubChem ID	16760706
InChI Key	QKAALLVQBOLELJ-UHFFFAOYSA-N
Smiles	Cl.NCCCCNS(=O)(=O)C1=CC=C2C(Cl)=CC=CC2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for W-13 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for W-13 hydrochloride

参考文献是支持产品生物活性的出版物。

Bosch et al (1998) Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21^cip1. J.Biol.Chem. 273 22145 PMID: 9705360

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736

Stroble and Peterson (1992) Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pim. and the calmodulin antagonist, W-13. J.Pharmacol.Exp.Ther. 263 186 PMID: 1403784

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关键词: W-13 hydrochloride, W-13 hydrochloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, W13, 0361, Tocris Bioscience

2 篇 W-13 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 W-13 hydrochloride 的部分引用包括：

Sethna et al (2016) Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. J Neurosci Res 94 401 PMID: 26864654

Yanda et al (2017) Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease. J Biol Chem 292 17897 PMID: 28887310