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说明： High affinity C5a receptor antagonist
化学名： N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for W 54011
W 54011 is a high affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).
化合物库 for W 54011
W 54011 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for W 54011
| 分子量 | 493.08 |
| 公式 | C30H36N2O2.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 405098-33-1 |
| PubChem ID | 5311121 |
| InChI Key | UKBJWRMNGCDKNL-UHFFFAOYSA-N |
| Smiles | CC(C)C1=CC=C(N(CC2=CC=C(N(C)C)C=C2)C(C3C(C=C(OC)C=C4)=C4CCC3)=O)C=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for W 54011
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 24.65 | 50 |
制备储备液 for W 54011
以下数据基于产品分子量 493.08。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.06 mL | 20.28 mL | 40.56 mL |
| 2.5 mM | 0.81 mL | 4.06 mL | 8.11 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 25 mM | 0.08 mL | 0.41 mL | 0.81 mL |
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产品说明书 for W 54011
参考文献 for W 54011
参考文献是支持产品生物活性的出版物。
Sumichika et al (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist. J.Biol.Chem. 277 49403 PMID: 12384495
Monk et al (2007) Function, structure and therapeutic potential of complement C5a receptors. Br.J.Pharmacol. 152 429 PMID: 17603557
Cho et al (2014) Autocrine effects of tumor-derived complement. Cell Rep. 6 1085 PMID: 24613353
If you know of a relevant reference for W 54011, please let us know.
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关键词: W 54011, W 54011 supplier, W54011, high, affinity, C5a, receptors, antagonists, antagonism, neutrophils, complement, Complement, 5455, Tocris Bioscience
2 篇 W 54011 的引用文献
引用文献是使用了 Tocris 产品的出版物。 W 54011 的部分引用包括：
Trent M et al (2021) Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Mol Cell 81 4605-4621.e11 PMID: 34582793
Sahu et al (2019) Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. Cell Rep 28 2567 PMID: 31484069
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